Chandigarh, April 6
A team of PGIMER doctors led by Prof. Dhandapani SS and Prof. Hemant Bhagat has published, for the first time in the world literature, on the molecular footprint of keyhole brain surgery compared with that of traditional neurosurgery in Neurosurgical Review, a reputed international journal.
Minimally invasive keyhole surgery is an evolving concept in Neurosurgery that aims to achieve a smaller opening in the skull to reach the target area with minimal collateral injury to nearby structures. It is used in a wide variety of diseases, including aneurysms and tumors. Though it is cosmetically better, with less post-operative pain and other side effects, there has never been solid evidence before this study on whether it is truly minimally invasive in terms of its biochemical footprint.
The PGIMER team of doctors, Dhandapani, Prasant, Tejasvi, Mukilan, Apinderpreet, Navneet, Vivek, Sushant, Chandrashekhar, Hemant, and SK Gupta have published a study in Neurosurgical Review on the comparison of levels of CRP, an inflammatory biomarker, and Caspase-3, an indicator of apoptosis, from before treatment to after treatment across various modalities, and shown keyhole surgery to have less inflammatory reaction than open neurosurgery. This is very relevant, as it shows why keyhole brain surgery can offer significant long-term benefits, such as reduced risk of post-operative seizures and cognitive deficits.
